期刊
JOURNAL OF HYPERTENSION
卷 22, 期 10, 页码 2007-2015出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004872-200410000-00025
关键词
autonomic nervous system; baroreflex control; glucose clamp technique; heart rate variability; insulin resistance; physical fitness
Objectives We hypothesized that insulin sensitivity and vagal cardiac control are independently related in young men after adjustment for fitness and other confounding variables. Design Male volunteers aged 21-24 years with high (borderline hypertensive; n=20) and low-normal (normotensive; n=21) screening blood pressure (BP) were studied cross-sectionally. Methods Mean R-R interval (RR) and heart rate variability (HRV) were computed from 30-min ECGs, and baroreflex sensitivity (BRS) and latency (phase shift) from 15-min beat-to-beat finger blood pressure (BP) and heart rate recordings. Insulin-adjusted glucose disposal rate (GDR/I) was measured with a 90-min hyperinsulinaemic glucose clamp and fitness by peak oxygen uptake (VO2peak) during a treadmill test. Results HRV, baroreflex function, GDR/I, and VO2peak did not differ between the groups. GDR/I correlated positively with time and frequency domain HRV, including high-frequency power (HF) (r=0.40, P=0.01) and root-mean squared successive differences (RMSSD) (r=0.43, P=0.005), but not BRS or phase shift. GDR/I correlated with VO2peak (r=0.70, P<0.0001) and was explained (R-2=0.56) by VO2peak (P=0.57, P<0.0001) and RR (beta=0.29, P=0.03), independently of H RV and measures of obesity. Conversely, RR (beta=0.55, P=0.0004) and H RV, including HF (beta=0.44, P=0.006) and RMSSD (beta=0.46, P=0.004) were explained by GDR/I, independently of VO2peak. Conclusions Insulin sensitivity and autonomic cardiac control are related independently of physical fitness in young men.
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