期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 97, 期 4, 页码 1567-1574出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00396.2004
关键词
lung resection; compensatory lung growth; high-resolution computed tomography scan; lobar tissue volume; mechanical lung strain; dog
资金
- NHLBI NIH HHS [R01 HL045716, HL-62873, R01 HL-40070, HL-45716, R01 HL054060, R01 HL062873, HL-54060, R01 HL040070] Funding Source: Medline
After pneumonectomy (PNX), mechanical strain on the remaining lung is greatly increased. To assess whether remaining lobes expand uniformly after left or right PNX (removing 42 and 58% of lung mass, respectively), we performed high-resolution computed tomography (CT) scans at 45 ml/kg above end-expiratory lung volume on adult male foxhounds after left or right PNX, which were compared with adult Sham controls. Air and tissue volumes were separately measured in each lobe. After left PNX, air and tissue volumes in the right upper and cardiac lobes increased similar to2.2-fold above and below the heart, whereas volumes in right middle and lower lobes did not change significantly. After right PNX, air and tissue volumes in the left upper and middle lobes increased 2.3- to 2.7-fold across the midline anterior to the heart, whereas the left lower lobe expanded similar to 1.9-fold posterior to the heart. Regional changes in volume density of tissue post-PNX estimated by CT scan parallel postmortem estimates by morphometric analyses. Data indicate heterogeneous regional distribution of mechanical lung strain, which could influence the differential cellular compensatory response following right and left PNX.
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