期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 15, 期 5, 页码 573-581出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2004.04.003
关键词
blastocyst; polarity; epiblast; trophoblast; primitive endoderm; transcription factors
The early events of mouse embryogenesis lead to the formation of three distinct cell lineages by the blastocyst: the pluripotent epiblast and the two extraembryonic lineages, the trophoblast and primitive endoderm. Segregation of the lineages depends on the relative levels of expression of key transcription factors, whose localized expression must be controlled by the earlier events of compaction and polarization of the morula. Soon after lineage specification, the two extraembryonic lineages show evidence of early polarities that may relate to the polarity of the postimplantation embryo at gastrulation. The exact relationship between lineage segregation, preimplantation polarities and the postimplantation axes remain to be determined but are now open to molecular and cellular investigation. (C) 2004 Elsevier Ltd. All rights reserved.
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