Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi

From the whole plant of Dracocephalum kotschyi Boiss., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1-8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), beta-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-beta-D-glueopyranoside (9), and limonen-10-ol 10-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (10). Compounds I (3.1 mum), 2 (3.1 mum), 3 (3.1 mum), 5 (6.2 mum), 6 (6.2 mum), and 8 (6.2 mum) were effective against epimastigotes of Trypanosoma cruzi.