期刊
SEMINARS IN IMMUNOLOGY
卷 16, 期 5, 页码 335-347出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2004.08.014
关键词
memory T cell; heterologous immunity; cross-reactive; allo-reactive; memory attrition
类别
资金
- NIAID NIH HHS [P01 AI049320, R01 AI054455, AI054455, AI46578, AI49320, R01 AI046578] Funding Source: Medline
- NIAMS NIH HHS [AR35506, R01 AR035506] Funding Source: Medline
- NIDDK NIH HHS [P30 DK032520, DK32520] Funding Source: Medline
Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen- specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells. (C) 2004 Elsevier Ltd. All rights reserved.
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