Human whole-blood relaxometry at 1.5T: Assessment of diffusion and exchange models

Human whole-blood relaxometry experiments were performed to allow the prediction of blood signal changes with blood oxygen saturation (Y) and refocusing interval (tau(180)). Such predictions are particularly relevant for spin-echo (SE) blood oxygenation level-dependent (BOLD) experiments and a recently proposed noninvasive fMRI method for measuring cerebral blood volume (CBV). Ensemble fitting of the entire set of T-2 estimates, obtained over an extensive range of Y and tau(180) values, was performed with the use of both a fast chemical exchange model and a model of diffusion in weak magnetic field in homogeneities. The diffusion modeling resulted in a large reduction in the residual sum-of-squares compared to the fast exchange modeling. The longitudinal relaxation rate decreased linearly with Y, and increased with hematocrit. The results support the application of the recently reported diffusion model to describe deoxyhemoglobin (dHb)-induced blood transverse relaxation rate enhancement at 1.5 T. (C) 2004 Wiley-Liss, Inc.