期刊
BIOLOGY OF THE CELL
卷 96, 期 8, 页码 603-615出版社
WILEY
DOI: 10.1016/j.biolcel.2004.04.013
关键词
electron microscopy; HERDS; immunocytochemistry; nuclear ribonucleoproteins; transcription
类别
The aim of this paper is to review the data in the literature concerning ribonucleoprotein components during apoptosis, where a major rearrangement of RNPs takes place. In parallel with chromatin changes, the nucleoplasmic constituents (perichromatin fibrils; perichromatin granules; interchromatin granules and nuclear bodies) as well as the nucleoli aggregate into heterogeneous clusters called HERDS, in the interchromatin space. Later, these RNP-containing structures are extruded from the nucleus and leave the cell within cytoplasmic blebs. We propose also a role for HERDS as markers of irreversible transcriptional arrest. (C) 2004 Elsevier SAS. All rights reserved.
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