期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 294, 期 6, 页码 395-399出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2004.07.012
关键词
Salmonella serotype enteritidis; invasion; flagella; motility; Caco-2 cells
The relative contributions of the flagellum and the flagella-associated bacterial motility in the invasion of Caco-2 cells by Salmonella serotype Enteritidis were investigated using an fliC mutant defective in flagellin production and a motA mutant that carries flagella but is non-motile. Infection assays demonstrated that, at I It of infection, both the fliC and the motA mutants were severely impaired in bacterial invasion compared to the parental strain. Infection assays at 3 h infection demonstrated virtually equal invasion levels for both non-motile mutants and the parental strain. Together these data suggest that flagella-mediated bacterial motility accelerates the invasion of Salmonella but is not required for the invasion event per se. (C) 2004 Elsevier GmbH. All rights reserved.
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