期刊
BIOLOGICAL PSYCHIATRY
卷 56, 期 7, 页码 531-534出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2004.06.035
关键词
cerebrospinal fluid; corticotropin-releasing factor; CRF; CSF; depression; HPA; hypothalamic-pituitary-adrenal; neuroendocrine; tryptophan depletion
资金
- NIMH NIH HHS [MH-52899, MH-42088] Funding Source: Medline
Background: Brain serotonin neurotransmission and hypothalamic-pituitary-adrenal axis function are implicated in the pathophysiology physiology of depression, and these systems interact in a reciprocal modulatory fashion. This study examined the effect depletion, which acutely reduces brain serotonin concentrations, on serial cerebrospinal fluid concentrations of corticotropin-releasing factor in healthy humans. Methods: Five subjects completed a standard tryptophan depletion protocol, and four subjects participated in a comparison condition. Subjects underwent continuous sampling of cerebrospinal fluid via lumbar peristaltic pump. Concentrations of cerebrospinal fluid corticotropin-releasing factor were measured by radioimmunoassay. Results: No mood changes were observed in either group. Tryptophan-depleted subjects exhibited significantly greater increases in corticotropin-releasing factor concentrations over time than subjects in the comparison condition. Conclusions: These findings highlight the potential importance of corticotropin-releasing factor and serotonin interactions and suggest that activation of corticotropin-releasing-factor-containg neurons could play a role in the emergence of mood symptoms following tryptophan depletion in vulnerable individuals.
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