期刊
DEVELOPMENT
卷 131, 期 19, 页码 4677-4686出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.01366
关键词
nuclear migration; dynein; capping protein; dynamitin; kinesin
资金
- NEI NIH HHS [R01 EY013874-04, R01 EY013874] Funding Source: Medline
How a nucleus is positioned within a highly polarized post-mitotic animal cell is not well understood. In this work, we demonstrate that the Dynactin complex (a regulator of the microtubule motor protein Dynein) is required to maintain the position of the nucleus within post-mitotic Drosophila melanogaster photoreceptor neurons. We show that multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain, and that inhibiting Dynactin causes the photoreceptor to acquire a bipolar appearance with long leading and trailing processes. We find that while the minus-end directed motor Dynein cooperates with Dynactin in positioning the photoreceptor nucleus, the plus-end directed microtubule motor Kinesin acts antagonistically to Dynactin. These data suggest that the maintenance of photoreceptor nuclear position depends on a balance of plus-end and minus-end directed microtubule motor function.
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