期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1050, 期 2, 页码 201-209出版社
ELSEVIER
DOI: 10.1016/j.chroma.2004.08.051
关键词
water analysis; pharmaceuticals; metabolites; residues; drinking water
A new analytical method applying in situ derivatization was developed to enable the extraction of polar drug metabolites from water samples by solid-phase extraction (SPE). An additional derivatization by silylation was used to enhance the sensitivity of analyte detection by gas chromatography-mass spectrometry (GC-MS). Thus, the two metabolites 1,5-di-methyl-1,2-dehydro-3-pyrazolone (DP) and 4-(2-methylethyl)-1,5-dimethyl-1,2-dehydro-3-pyrazolone (PDP), postulated for the degradation of phenazone and propyphenazone, were identified and detected up to the mug/L level in raw and drinking water samples from public water supply. (C) 2004 Elsevier B.V. All rights reserved.
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