期刊
BRITISH JOURNAL OF CANCER
卷 91, 期 7, 页码 1380-1383出版社
SPRINGERNATURE
DOI: 10.1038/sj.bjc.6602125
关键词
lung carcinogenesis; benzo[alpha] pyrene; resveratrol; adducts; CYP1A1; CYP1B1
类别
Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[ a] pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[ a] pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.
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