期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 56, 期 12, 页码 1765-1791出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2004.07.008
关键词
peptide transporters; proton-coupled oligopeptide transporters; PEPT2; choroid plexus; central nervous system; drug delivery; drug efflux; neuropeptides; hormones; peptidomimetics
资金
- NHLBI NIH HHS [P01 HL018575] Funding Source: Medline
- NIGMS NIH HHS [R01 GM035498] Funding Source: Medline
- NINDS NIH HHS [R01 NS034709, R01 NS027601] Funding Source: Medline
In addition to being the main source of cerebrospinal fluid (CSF) secretion, the choroid plexuses are involved in the supply and distribution of peptides to brain, the removal of toxic metabolites, the excretion of xenobiotics, and the delivery of drugs as an alternative route to the blood-brain barrier (BBB). The discovery of proton-coupled oligopeptide transporters in choroid plexus has generated considerable interest regarding their physiologic role at the blood-cerebrospinal fluid interface and their potential for peptide/antagonist pharmacotherapy in the central nervous system. Many of the same factors that affect the disposition of naturally occurring peptides in brain will also affect the disposition of exogenously delivered peptide or peptidomimetic drugs. Therefore, this review addresses three main areas: (1) choroid plexus structure, physiology, and barrier function in relation to peptide transport; (2) polypeptide transport and secretion mechanisms into cerebrospinal fluid; and (3) molecular physiology. expression, and functional activity of proton-coupled oligopeptide transporters in choroid plexus. (C) 2004 Published by Elsevier B.V.
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