Regioselective enzymatic acylation of β-L-2′-deoxynucleosides:: Application in resolution of β-D/L-2′-deoxynucleosides

(GRAPHICS) A practical synthesis Of beta-L-3'- and beta-L-5'-O-levulinyl-2'-deoxynucleosides has been described for the first time through enzymatic acylation and/or hydrolysis processes. It is noteworthy that the different behavior exhibited by Pseudomonas cepacia lipase in the acylation of D- and L-nucleosides allows the parallel kinetic resolution Of D/L-nucleosides.