期刊
NEURON
卷 44, 期 2, 页码 251-261出版社
CELL PRESS
DOI: 10.1016/j.neuron.2004.09.028
关键词
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资金
- NIDA NIH HHS [R01DA12462] Funding Source: Medline
- NIMH NIH HHS [R01MH51561, K02MH01046, R01MH49428] Funding Source: Medline
Most cortical interneurons arise from the subcortical telencephalon, but the molecules that control their migration remain largely unidentified. Here, we show that different isoforms of Neuregulin-1 are expressed in the developing cortex and in the route that migrating interneurons follow toward the cortex, whereas a population of the migrating interneurons express ErbB4 a receptor for Neuregulin-1. The different isoforms of Neuregulin-1 act as short- and long-range attractants for migrating interneurons, and perturbing ErbB4 function in vitro decreases the number of interneurons that tangentially migrate to the cortex. In vivo, loss of Neuregulin-1/ErbB4 signaling causes an alteration in the tangential migration of cortical interneurons and a reduction in the number of GABAergic interneurons in the postnatal cortex. These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system.
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