Cp2Fe(PR2)2PdCl2 (R = i-Pr, t-Bu) complexes as air-stable catalysts for challenging suzuki coupling reactions

The use Of CP2Fe(PR2)(2)PdCl2 (R = i-Pr and t-Bu) in Suzuki coupling reactions were illustrated using a high throughput screening approach. The di-tbpfPdCl(2) catalyst was shown to be the more active catalyst for unactivated and sterically challenging aryl chlorides. Comparison studies using the commercial catalysts dppfPdCl(2), (Ph3P)(2)PdCl2, (Cy3P)(2)PdCl2, DPEPhosPdCl(2), dppbPdCl(2), dppePdCl(2), Pd(t-BU3P)(2), and [Pd-(mu-Br)(t-Bu3P)](2) were also done for selected cases to demonstrate the superior activities of di-tbpfPdCl(2) and di-isoppfPdCl(2).