期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 37, 期 8, 页码 1097-1104出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2004.07.008
关键词
heme oxygenase-1; gene; polymorphism; promoter; review; free radicals
Heme oxygenase (HO) seems to be a novel protective factor with potent anti-inflammatory, anti-oxidant, and anti-proliferative effects. HO-1, the inducible isoform, is expressed in various tissues and is upregulated by multiple stimuli. However, humans differ quantitatively in their ability to mount an HO-1 response, modulated by two potentially functional polymorphisms in the HO-1 gene promoter region. From several studies it seems that the ability of a patient with certain genotypes to respond strongly in terms of upregulating HO-1 may be an important endogenous protective factor. In the present article we systematically review the hitherto published evidence that promoter polymorphisms in the HO-1 gene exert functional importance by influencing the level of HO-1 expression in different organ systems. (C) 2004 Elsevier Inc. All rights reserved.
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