期刊
JOURNAL OF IMMUNOLOGY
卷 173, 期 8, 页码 5121-5129出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.8.5121
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The proviral load in human T cell lymphotropic virus type 1 (HTLV-1) infection is typically constant in each infected host, but varies by > 1000-fold between hosts and is strongly correlated with the risk of HTLV-1-associated inflammatory disease. However, the factors that determine an individual's HTLV-1 proviral load remain uncertain. Experimental evidence from studies of host genetics, viral genetics, and lymphocyte function and theoretical considerations suggest that a major determinant of the equilibrium proviral load is the CD8(+) T cell response to HTLV-1. In this study, we tested the hypothesis that the gene expression profile in circulating CD8(+) and CD4(+) lymphocytes distinguishes between individuals with a low proviral load of HTLV-1 and those with a high proviral load. We show that circulating CD8(+) lymphocytes from individuals with a low HTLV-1 proviral load overexpressed a core group of nine genes with strong functional coherence: eight of the nine genes encode granzymes or other proteins involved in cell-mediated lysis or Ag recognition. We conclude that successful suppression of the HTLV-1 proviral load is associated with strong cytotoxic CD8(+) lymphocyte activity in the peripheral blood.
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