A facile regioselective ring opening of aziridines to haloamines using tetrabutylammonium halides in the presence of β-cyclodextrin in water

A variety of N-tosylaziridines undergo regioselective ring opening with tetrabutylammonium halides in the presence of beta-cyclodextrin in water at pH 4 and room temperature to afford the corresponding haloamines in excellent yields. (C) 2004 Elsevier Ltd. All rights reserved.