期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 42, 页码 15172-15177出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0406242101
关键词
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资金
- NCI NIH HHS [P50 CA062924, CA 43460, CA 92871, U24 CA092871, R24 CA092871, R37 CA043460, CA 062924] Funding Source: Medline
- NCRR NIH HHS [RR 00171, K26 RR000171] Funding Source: Medline
- NIDCD NIH HHS [T32 DC 00027, T32 DC000027] Funding Source: Medline
When spores of the anaerobic bacterium Clostridium novyi-NT are systemically injected into animals, they germinate exclusively within the hypoxic regions of cancers. The germinated bacteria destroy adjacent tumor cells but spare a rim of well oxygenated tumor cells that subsequently expand. Surprisingly, we found that approximate to30% of mice treated with such spores were cured of their cancers despite the viable tumor rim initially remaining after spore germination. The mechanism underlying this effect was shown to be immune-mediated, because cured animals rejected a subsequent challenge of the same tumor. Similar effects were observed in rabbits with intrahepatic tumors. It was particularly notable that the induced immune response, when combined with the bacteriolytic effects of C novyi-NT, could eradicate large established tumors.
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