期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 69, 期 22, 页码 7758-7760出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo048890e
关键词
-
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0618] Funding Source: Medline
Solvent-free per-O-acetylation of sugars with stoichiometric acetic anhydride and catalytic iodine proceeds in high yield (90-99%) to give exclusively pyranose products as anomeric mixtures. Without workup, subsequent anomeric substitution employing iodine in the presence of hexamethyldisilane (i.e., TMS-I generated in situ) gives the corresponding glycosyl iodides in 75-95% isolated yield. Alternatively, and without workup, further treatment with dimethyl disulfide or thiol (ethanethiol or thiocresol) gives anomerically pure thioglycosides in more than 75% overall yield.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据