期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 323, 期 4, 页码 1293-1298出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2004.09.006
关键词
IEX-1; gly96; 1,25-dihydroxyvitamin D; apoptosis
资金
- NIAMS NIH HHS [R01 AR053220-04, R01 AR053220] Funding Source: Medline
- NIDDK NIH HHS [DK25409, R01 DK025409, R01 DK058546, R01 DK065830] Funding Source: Medline
- BLRD VA [I01 BX002647] Funding Source: Medline
Immediate early gene X-1 (IEX-1) modulates apoptosis, cellular growth, mechanical strain-induced cardiac hypertrophy, and vascular intimal hyperplasia. To determine how IEX-1 alters apoptosis, we performed yeast two-hybrid studies using IEX-1 as the bait protein, and examined interactions between IEX-1 and proteins expressed by a human kidney cDNA expression library. We found that IEX-1 interacts with several proteins of which at least four are known to play a role in the regulation of apoptosis: (1) calcium-modulating cyclophilin ligand; (2) tumor necrosis factor-related apoptosis-inducing ligand (tumor necrosis factor superfamily, member 10); (3) ML-1 myeloid cell leukemia gene encoded protein; and (4) BAT3, a gene present in the major histo-compatibility complex. Our data suggest that IEX-1 may regulate apoptosis by directly interacting with various proteins involved in the control of apoptotic pathways. (C) 2004 Elsevier Inc. All rights reserved.
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