期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 47, 期 12, 页码 891-894出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/jlcr.879
关键词
base-catalyzed exchange; tritium; labelled compounds; aryl methyl ketone; diketone
A synthesis and a base-catalyzed exchange reaction was developed under mild conditions to deuterate and subsequently tritiate the methyl group of the base sensitive diketone 1-biphenyl-4-ylpropane-1,2-dione depicted in Figure 1. Using Et3N as base, deuterium incorporation of the methyl group was 88.9% and the tritium incorporation gave a specific radioactivity of 119 mCi/mmol. The scope of the exchanges was extended to methyl aryl ketones 2-4. Copyright (C) 2004 John Wiley Sons, Ltd.
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