期刊
JOURNAL OF NATURAL PRODUCTS
卷 67, 期 11, 页码 1942-1946出版社
AMER CHEMICAL SOC
DOI: 10.1021/np040078j
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Annoglabayin (1), a novel Annona dimeric kaurane diterpenoid, has been isolated from Annona glabra, and its structure was determined on the basis of spectroscopic analysis. Annoglabayin (1) contains a unique carbon bridge between two nor-ent-kaurane monomeric units. The dose-response of 2 in Hep G2 cells indicated that 2 increased DNA damage. In addition, our results showed that 2 induced a noticeable decrease in mitochondrial transmembrane potential during treatment. These results indicate that 2 produces apoptotic events in Hep G2 cells, through inducing changes in mitochondria.
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