期刊
APPLIED PHYSICS LETTERS
卷 98, 期 16, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3548564
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资金
- NSF [0754880, 0930501]
- Office of Naval Research (ONR)
- Office of The Director, National Institutes of Health [DP2OD006427]
- Bill-Melinda Gates Foundation
- Vodafone Americas Foundation
- Directorate For Engineering [0930501] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0754880] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [0930501] Funding Source: National Science Foundation
Using lensfree holography we demonstrate optofluidic tomography on a chip. A partially coherent light source is utilized to illuminate the objects flowing within a microfluidic channel placed directly on a digital sensor array. The light source is rotated to record lensfree holograms of the objects at different viewing directions. By capturing multiple frames at each illumination angle, pixel super-resolution techniques are utilized to reconstruct high-resolution transmission images at each angle. Tomograms of flowing objects are then computed through filtered back-projection of these reconstructed lensfree images, thereby enabling optical sectioning on-a-chip. The proof-of-concept is demonstrated by lensfree tomographic imaging of C. elegans. (C) 2011 American Institute of Physics. [doi:10.1063/1.3548564]
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