期刊
CLINICAL IMMUNOLOGY
卷 113, 期 2, 页码 130-136出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2004.08.012
关键词
granuloma; T cell; mycobacterium
类别
资金
- NIAID NIH HHS [R21 AI054893, R01 AI48087, R01 AI/HL46430] Funding Source: Medline
Chronic infection with mycobacteria is controlled by the formation of granulomas. The failure of granuloma maintenance results in reactivation of disease. Macrophages are the dominant cell type in granulomas, but CD4(+) T cells are the master organizers of granuloma structure and function. Recent work points to an unrecognized role for nonspecific T cells in maintaining granuloma function in the chronic phase of infection. In addition, it has become clear that mycobacteria and host T cells collaborate in formation of granulomas. Further understanding of how nonspecific T cells contribute to granuloma formation, as well as how bacteria and T cells maintain a harmonious relationship over the life of the host, will facilitate the development of new strategies to treat mycobacterial disease. (C) 2004 Published by Elsevier Inc.
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