期刊
PAIN
卷 112, 期 1-2, 页码 156-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.pain.2004.08.010
关键词
allodynia; GABA; glycine; hyperalgesia; neuropathic pain; tonic inhibition
Inhibitory mechanisms are essential in suppressing the development of allodynia. and hyperalgesia in the normal animal and there is evidence that loss of inhibition can lead to the development of neuropathic pain. We used Fos expression to map the distribution of tonically inhibited cells in the healthy rat lumbar spinal cord. In a control group, Fos-like immunoreactive (Fos-LI) cells were rare, averaging 7.5 +/- 2.2 cells (mean+/-SEM; N= 13 sections) per 20 mum thick section of dorsal horn. This rose to 103+/-11 (mean+/-SEM; N=20) in picrotoxintreated rats and to 88 +/- 11 (mean+/-SEM; N= 18) in strychnine-treated rats. These changes were significant (ANOVA; P < 0.00 1). There were marked regional variations in the distribution of Fos-LI cells between picrotoxin- and strychnine-treated animals. Picrotoxin induced a significant increase in the number of Fos-LI cells throughout the dorsal horn (lamina I-VI) while strychnine significantly elevated Fos-like immunoreactivity only in deep laminae (III-VI). For both picrotoxin and strychnine, the increase in Fos-like immunoreactivity peaked in lamina V (at 3579 +/- 319 and 3649 +/- 375% of control, respectively; mean+/-SEM) but for picrotoxin an additional peak was observed in the outer part of lamina 11 (1959 +/- 196%). Intrathecal administration of both GABA(A) and glycine receptor antagonists has been shown elsewhere to induce tactile allodynia. The present data suggest that this allodynia could arise due to blockade of tonic GABAA and glycine-receptor mediated inhibition in the deep dorsal horn. GABAA antagonists also induce hypersensitivity to noxious inputs. The blockade of tonic inhibition in the superficial dorsal horn shown here may underlie this hyperalgesia. (C) 2004 Intemational Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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