期刊
APPLIED PHYSICS LETTERS
卷 99, 期 25, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3671078
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资金
- National Science Council in Taiwan [NSC 99-2218-E-182-005]
Solid-state sensors are stable and inexpensive electric transducers for biomedical measurement. This study proposes a microfluidic chip incorporated with a solid-state sensor for measuring glucose and creatinine in blood serum. Magnetic beads are employed to immobilize enzymes and deliver them in a micro-channel. Glucose and creatinine can be measured at 2-8 mM and 10(-2) to 10 mM, respectively, which is a meaningful range in human blood. The immobilization approach also addresses the issue of the long-term preservation of enzymes in microfluidic devices. The proposed device is suitable for multi-target measurement in a point-of-care system. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3671078]
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