期刊
PHARMACOGENETICS
卷 14, 期 11, 页码 779-781出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008571-200411000-00010
关键词
azathioprine; 6-mercaptopurine; ITPA; inosine triphosphate pyrophosphatase; thiopurine methyltransferase; adverse effects; inflammatory bowel disease
A 94C>A missense mutation in the ITPA gene which encodes inosine triphosphate pyrophosphatase has been associated with adverse effects from azathioprine, specifically flu-like symptoms, pancreatitis and rash. We hypothesized that this association may also be present in a larger, population-based group of inflammatory bowel disease patients intolerant of thiopurine drugs. We performed genotyping for this polymorphism and TPMT*2 and TPMT*3 in 73 such patients and 74 patients with inflammatory bowel disease who have tolerated azathioprine. We could not demonstrate a significant association between the ITPA94C>A genotype and any adverse effects (Odds ratio (OR) 1.015, 95% confidence interval (CI) 0.360-2.867, P = 0.593), flu-like symptoms (OR 1.547, 95% CI 0.368-6.496, P = 0.398), rash (no ITPA 94C>A polymorphism identified) or pancreatitis (no ITPA 94C>A polymorphism identified). We found no significant association between the ITPA 94C>A polymorphism and adverse effects to thiopurine drugs. (C) 2004 Lippincott Williams Wilkins.
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