期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 52, 期 11, 页码 1391-1393出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.1391
关键词
hypromellose acetate succinate; molecular weight; SEC-MALLS; hydroxypropyl methylcellulose acetate succinate; laser light scattering
The molecular weight of hypromellose acetate succinate (HPMCAS), a polymer used for enteric coating, was determined by means of size exclusion chromatography with a multi-angle laser light scattering detector. The weight-average molecular weight (Mw) of several lots and grades ranged approximately from 17000 to 20000, and the number-average molecular weight (Mn) was around 13000. The inter-day precision of measurement, in terms of the coefficient of variation, was less than 5%.
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