期刊
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
卷 95, 期 5, 页码 215-219出版社
BLACKWELL MUNKSGAARD
DOI: 10.1111/j.1742-7843.2004.pto950503.x
关键词
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We investigated the inhibitory effect of stinging nettle leaf extract on the protease activity of botulinum neurotoxin type A and B light chains. The nettle leaf infusion was fractionated and HPLC-based enzymatic assays were performed to determine the capacity of each fraction to inhibit the protease activity of botulinum neurotoxin type A and B light chains. Assay results demonstrated that a water-soluble fraction obtained from the nettle leaf infusion inhibited type A, but did not inhibit type B light chain protease activity. The inhibition mode of water soluble fraction against protease activity of type A light chain was analyzed and found to be a non-competitive.
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