期刊
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
卷 116, 期 5, 页码 2832-2842出版社
ACOUSTICAL SOC AMER AMER INST PHYSICS
DOI: 10.1121/1.1795334
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资金
- NIBIB NIH HHS [8R01 EB00350-2] Funding Source: Medline
Light scattering was used to measure the radial pulsations of individual ultrasound contrast microbubbles subjected to pulsed ultrasound. Highly diluted Optison(R) or Sonazoid(R) microbubbles were injected into either a water bath or an aqueous solution containing small quantities of xanthan gum. Individual microbubbles were insonified by ultrasound pulses from either a commercial diagnostic ultrasound machine or a single element transducer. The instantaneous response curves of the microbubbles were measured. Linear and nonlinear microbubble oscillations were observed. Good agreement was obtained by fitting a bubble dynamics model to the data. The pulse-to-pulse evolution of individual microbubbles was investigated, the results of which suggest that the shell can be semipermeable, and possibly weaken with subsequent pulses. There is a high potential that light scattering can be used to optimize diagnostic ultrasound techniques, understand microbubble evolution, and obtain specific information about shell parameters. (C) 2004 Acoustical Society of America.
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