期刊
JOURNAL OF PEDIATRICS
卷 145, 期 5, 页码 593-599出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2004.05.042
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资金
- NICHD NIH HHS [HD-07162] Funding Source: Medline
- NINDS NIH HHS [NS35902] Funding Source: Medline
Objectives To determine if the incidence of sonographically detected cystic periventricular leukomalacia (PVL) and periventricular hemorrhagic infarction (PVHI) have changed over the past decade and to determine if a decline in cystic PVL was associated with a change in neurodevelopmental outcome. Study design Premature newborn infants admitted to our intensive care nursery from 1992 to 2002 were identified in a comprehensive nursery database. Premature newborn infants had routine neurosonography by means of a standardized protocol. Infants weighing less than or equal to1500 g at birth surviving to nursery discharge were enrolled in a nursery follow-up clinic. Results Adjusting for gestational age, there was a significant decrease in cystic PVL from 1992 to 2002 (P = .003) without a concurrent decrease in PVHI (P = 0.5). Cystic PVL and PVHI accounted for only 9 of the 28 cases of cerebral palsy and 12 of 90 cases of abnormal Developmental Scores in infants weighing <1500 g at birth. The decline in cystic PVL was not associated with improved developmental outcome from 1992 to 2002. Conclusions The incidence of cystic PVL declined significantly from 1992 to 2002 at our center. Cystic PVL was detected by ultrasound in a minority of infants with abnormal neurodevelopmental outcome, indicating that other forms of cerebral injury account for the majority of abnormal neurodevelopmental outcomes in premature newborn infants.
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