期刊
APPLIED PHYSICS LETTERS
卷 99, 期 26, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3673277
关键词
biological techniques; biotransport; Brownian motion; DNA; free energy; genetics; molecular biophysics; molecular configurations; nanobiotechnology; nanofluidics
We demonstrate free energy landscaping, a method for controlling the transport and conformations of DNA in nanofluidic devices with a nanotopography. A device that funnels molecules into traps where they adopt the shapes of letters illustrates the principle. We analyze how the nanotopography establishes regions of lower free energy and how entropic forces compete with advection, Brownian motion, and, importantly, excluded volume interactions; a rise in the density of DNA can be induced to facilitate its escape from a trap at a controlled location. An ability to guide DNA into solvent-permeable traps makes free energy landscaping applicable to genetic analyses. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3673277]
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