期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 52, 期 11, 页码 1269-1272出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.1269
关键词
Vitex negundo; Verbinaccae; lignan; lipoxygenase; cholinesterase inhibition
Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.
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