Synthesis of [O-methyl-11C]-4-(1,3-dimethoxy-2-propylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)[1,5-a]pyrazolo-1,3,5-triazine ([11C]DMP696):: a potential PET ligand for CRF1 receptors

Synthesis of [O-methyl-C-11]-4-(1,3-dimethoxy-2-propylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)[1,5-a]pyrazolo-1,3,5-triazine ([C-11]DMP696), a highly selective CRF1 antagonist has been achieved. The total time required for the synthesis of [C-11]DMP696 is 30 min from EOB, using [C-11]methyl triflate in THF, with a 16% yield (EOS) and >99% chemical and radiochemical purities along with a specific activity of >2000 Ci/mmol (EOS). Copyright (C) 2004 John Wiley Sons, Ltd.