期刊
CELL DEATH AND DIFFERENTIATION
卷 11, 期 11, 页码 1198-1203出版社
SPRINGERNATURE
DOI: 10.1038/sj.cdd.4401488
关键词
apoptosis; germline development; p53; RNAi; C. elegans
资金
- NIGMS NIH HHS [GM52240] Funding Source: Medline
- Wellcome Trust [054523] Funding Source: Medline
We used genome-wide RNA interference (RNAi) to identify genes that affect apoptosis in the C. elegans germ line. RNAi-mediated knockdown of 21 genes caused a moderate to strong increase in germ cell death. Genetic epistasis studies with these RNAi candidates showed that a large subset (16/21) requires p53 to activate germ cell apoptosis. Apoptosis following knockdown of the genes in the p53-dependent class also depended on a functional DNA damage response pathway, suggesting that these genes might function in DNA repair or to maintain genome integrity. As apoptotic pathways are conserved, orthologues of the worm germline apoptosis genes presented here could be involved in the maintenance of genomic stability, p53 activation, and fertility in mammals.
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