期刊
NATURE NEUROSCIENCE
卷 7, 期 11, 页码 1222-1232出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1331
关键词
-
资金
- NCI NIH HHS [R01 CA107193, CA107193, R01 CA107193-03] Funding Source: Medline
- NINDS NIH HHS [NS19090, R01 NS019090] Funding Source: Medline
Although netrins are an important family of neuronal guidance proteins, intracellular mechanisms that mediate netrin function are not well understood. Here we show that netrin-1 induces tyrosine phosphorylation of proteins including focal adhesion kinase (FAK) and the Src family kinase Fyn. Blockers of Src family kinases inhibited FAK phosphorylation and axon outgrowth and attraction by netrin. Dominant-negative FAK and Fyn mutants inhibited the attractive turning response to netrin. Axon outgrowth and attraction induced by netrin-1 were significantly reduced in neurons lacking the FAK gene. Our results show the biochemical and functional links between netrin, a prototypical neuronal guidance cue, and FAK, a central player in intracellular signaling that is crucial for cell migration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据