Triphenyl phosphine adducts of platinum(IV) and palladium(II) dithiocarbamates complexes: a spectral and in vitro study

Triphenyl phosphine adducts of dithiocarbamate complexes of platinum(IV) and palladium(II) of the type [Pt(L)(2)PPh3Cl2] and [Pd(L)(2)PPh3] [L: morpholine dithiocarbarnate (L-1), aniline dithiocarbarnate (L-2) and N-(methyl, cyclohexyl) dithiocarbamate (L-3)] were prepared and characterized by elemental analysis, electronic, IR, H-1 NMR and C-13 NMR spectral studies. Thermal studies of the complexes were carried out. In vitro antitumor activity has been screened towards human adenocarcinoma cell lines and showed significant inhibition even at very low concentration. (C) 2004 Elsevier B.V. All rights reserved.