期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 27, 期 11, 页码 1797-1803出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.27.1797
关键词
alpha-glucosidase; caffeoylquinic acid; propolis; antihyperglycemic effect; diabetes
To clarify the suppression of postprandial blood glucose rise via c glucosidase (AGH) inhibitory action by natural compounds, propolis was examined in this study. A single oral administration of propolis extract (50% methanol fraction on XAD-2 column chromatography) in Sprague-Dawley rats demonstrated a potent antihyperglycemic effect with the significant AUC(0-120 min) reduction of 38% at a dose of 20 mg/kg compared to that of controls. Among the active compounds isolated from the fraction, 3,4,5-tri-caffeoylquinic acid was found to be a prominent candidate that exerts the effect and shows a strong maltase-specific inhibition with an IC50 value of 24 mum. In addition, the noncompetitive inhibition power apparently increased with the number of caffeoyl groups bound to quinic acid.
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