期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 11, 页码 1805-1812出版社
WILEY
DOI: 10.1359/JBMR.040805
关键词
interleukin-1; TNF; growth plate; chondrocytes; insulin-like growth factor I
We hypothesized that pro-inflammatory cytokines can act locally in the growth plate to impair longitudinal growth. In a model of cultured fetal rat metatarsal bones, we found that IL-1beta and TNF-alpha act in synergy to inhibit longitudinal growth, an effect linked to decreased proliferation and increased apoptosis of growth plate chondrocytes. IGF-I could partially reverse all these effects.
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