期刊
JOURNAL OF CLINICAL PSYCHIATRY
卷 65, 期 11, 页码 1480-1482出版社
PHYSICIANS POSTGRADUATE PRESS
DOI: 10.4088/JCP.v65n1106
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Background: Recent reports raise the possibility that olanzapine can assist weight gain and improve behavioural symptoms during refeeding in anorexia nervosa. Method: Seventeen DSM-IV anorexia nervosa subjects hospitalized between May 1999 and October 2000 were enrolled in open-label treatment with olanzapine for up to 6 weeks. Baseline weight and symptoms were compared to patients' status at the end of treatment. Results: Olanzapine administration was associated with a significant reduction in depression, anxiety, and core eating disorder symptoms, and a significant increase in weight. A comparison with our historical data suggests that subjects in this study had a significantly greater decrease in depression. Conclusion: These data lend support to the possibility that olanzapine may be useful in treating anorexia nervosa. However, a controlled trial is necessary to demonstrate that olanzapine is efficacious.
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