期刊
PHYTOTHERAPY RESEARCH
卷 18, 期 11, 页码 934-937出版社
WILEY
DOI: 10.1002/ptr.1420
关键词
antimycobacterial constituents; isonicotinic acid hydrazide; atypical mycobacteria; synergism; Mycobacterium tuberculosis H37Rv
The synergistic activity of antimycobacterial constituents from Saudi plants was evaluated in combination with isonicotinic acid hydrazide (INH) against four atypical organisms, namely, Mycobacterium intracellulare, M. smegmatis, M. xenopei and M. chelonei. The potency of INH was increased four-fold, using an in vitro checkerboard method, against each mycobacteria when tested with a subtoxic concentration of the totarol, isolated from J. procera. The MIC values of totarol, ferulenol (from Ferula communis) and plumbagin (from Plumbago zeylanica) were thus lowered from 1.25-2.5 to 0.15-0.3 mug/mL due to synergism with INH. When tested against the resistant strain of M. tuberculosis H37Rv, plumbagin and 7beta-hydroxyabieta-8,13-dien-11,12-dione exhibited inhibitory activity at <12.5 mug/mL, while others were inactive at this concentration. Copyright (C) 2004 John Wiley Sons, Ltd.
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