期刊
BRITISH JOURNAL OF CANCER
卷 91, 期 9, 页码 1633-1638出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602163
关键词
mucin; MUC1; MUC4; pancreatic cancer; diagnosis; therapy
类别
资金
- NCI NIH HHS [R01 CA078590, R01 CA78590] Funding Source: Medline
Mucins are members of an expanding family of large multifunctional glycoproteins. Pancreatic mucins have important biological functions, including the protection, lubrication, and moisturisation of the surfaces of epithelial tissues lining ductal structures within the pancreas. Several lines of evidence support the notion that deregulated mucin production is a hallmark of inflammatory and neoplastic disorders of the pancreas. Herein, we discuss the factors that contribute to the lethality of pancreatic cancer as well as the key role played by mucins, particularly MUC1 and MUC4, in the development and progression of the disease. Aspects pertaining to the aberrant expression and glycosylation of mucins are discussed, with special emphasis on their potential impact on the design and implementation of adequate diagnostic and therapeutic strategies for combating this lethal malignancy.
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