期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 156, 期 1-2, 页码 74-87出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.07.009
关键词
calcium imaging; chemokine; IP-10; immunohistochemistry; intracellular calcium; rat
资金
- NIMH NIH HHS [MH63712] Funding Source: Medline
In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10, on the physiology of hippocampal neurons maintained in primary culture. CXCL10 elicited a rise in intracellular Ca2+ and enhanced both spontaneous and evoked electrical activity of hippocampal neurons. CXCL10-induced elevations in intracellular Ca2+ were associated with an increase in neuronal firing and an alteration in the relationship between the evoked Ca2+ Signal and neuronal activity. The effects of CXCL10 were not accompanied by a shift in resting membrane potential (RMP) or input resistance. Expression of the CXCR3 chemokine receptor supports a direct effect of CXCL10 on hippocampal neurons. (C) 2004 Elsevier B.V. All rights reserved.
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