期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 156, 期 1-2, 页码 31-41出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2004.06.015
关键词
B lymphocytes; antibodies; transgenic; germinal center; immunization; follicular dendritic cell
资金
- NIAID NIH HHS [T32 AI07472] Funding Source: Medline
- NIMH NIH HHS [R01 MH55722] Funding Source: Medline
xCorticotropin-releasing hormone (CRH) is a central mediator in the response to stress, coordinating behavioral, autonomic and neuroendocrine activation. CRH overproduction is implicated in several affective disorders, including major depression, panic-anxiety disorder and anorexia-diseases also associated with altered immune function. We investigated the link between CRH overdrive and immune function using CRH transgenic mice. Following immunization, CRH transgenic mice fail to form germinal centers; chronic glucocorticoid administration recapitulates this effect in wild-type mice. Regulation of germinal centers by glucocorticoids appears to be mediated, in part, through effects on follicular dendritic cells (FDC), providing a novel mechanism by which CRH dysregulation may significantly impair humoral immune responses. (C) 2004 Elsevier B.V. All rights reserved.
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