期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 71A, 期 2, 页码 250-257出版社
WILEY
DOI: 10.1002/jbm.a.30154
关键词
alumina; silicon; bone ingrowth; bone remodeling; osteogenesis; porosity; surface modification
The effect of doping a porous bioinert bioceramic with silicon (Si) on tissue ingrowth, differentiation, and osteogenesis was studied using a rat intramedullary model. Alumina tubes (1.3-mm outer diameter, 0.6-mm inner diameter, 15-mm. length) doped with Si at nominal concentrations of 0.5 and 5.0 mol % were implanted into femoral medullary canals of female rats for 16 weeks. Tissue formation within the tubes was determined by histology and histomorphometry. Addition of 0.5 mol % Si to alumina stimulated cellular activity at the bone-ceramic interface and impaired osteogenic maturation within the tubes. In contrast, osteogenesis was enhanced in the 5.0 mol % Si-doped alumina tubes. It is considered that effect of Si is related to surface chemistry rather than microstructure. This work demonstrates that doping a bioinert ceramic with small amounts of Si can significantly alter tissue ingrowth, differentiation, and osteogenesis within a porous implant. (C) 2004 Wiley Periodicals, Inc.
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