期刊
MOLECULAR BIOLOGY OF THE CELL
卷 15, 期 11, 页码 4971-4989出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E04-04-0296
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- NIGMS NIH HHS [GM-59216, R01 GM059216, R01 GM039066, GM-39066] Funding Source: Medline
Bud growth in yeast is guided by myosin-driven delivery of secretory vesicles from the mother cell to the bud. We find transport occurs along two sets of actin cables assembled by two formin isoforms. The Bnr1p formin assembles cables that radiate from the bud neck into the mother, providing a stable mother-bud axis. These cables also depend on septins at the neck and are required for efficient transport from the mother to the bud. The Bni1p formin assembles cables that line the bud cortex and target vesicles to varying locations in the bud. Loss of these cables results in morphological defects as vesicles accumulate at the neck. Assembly of these cables depends on continued polarized secretion, suggesting vesicular transport provides a positive feedback signal for Bni1p activation, possibly by rho-proteins. By coupling different formin isoforms to unique cortical landmarks, yeast uses common cytoskeletal elements to maintain stable and dynamic axes in the same cell.
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