期刊
DRUG NEWS & PERSPECTIVES
卷 17, 期 9, 页码 563-578出版社
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/dnp.2004.17.9.872570
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资金
- NCI NIH HHS [R01 CA90744] Funding Source: Medline
- NIDDK NIH HHS [R01 DK47015] Funding Source: Medline
dThe human aldo-keto reductase 1 C (AKR1C) isozymes are implicated in the pre-receptor regulation of steroid receptors, nuclear orphan receptors and membrane-bound ligand-gated ion channels. Human AKR members that may regulate the local concentration of steroid hormones include: AKR1C1, AKR1C2, AKR1C3, AKR1C4 and AKR1D1. Since, these enzymes are pluripotent, the physiological role for the human AKR1C isozymes is determined by their tissue-specific expression patterns and their substrate availability in target tissues. AKRs work in concert with short-chain dehydrogenases/reductases as switches to control ligand access to nuclear receptors. Consequently, they are potential targets in treating prostate cancer, breast cancer, endometriosis and endometrial cancer. (C) 2004 Prous Science. All rights reserved.
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