期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 21, 页码 5347-5350出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.08.015
关键词
diallyldisulphide; hypercholesterolemia; HMG-CoA reductase
A series of bis[3-(4'-substituted phenyl)prop-2-ene]disulfides were prepared and their hypolipidemic activities were examined in hypercholesterolemic Wistar rats. Introduction of an electron withdrawing group to the phenyl ring in the parent compound led to the identification of compound 8 as a potent and efficacious hypolipidemic agent. (C) 2004 Elsevier Ltd. All rights reserved.
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